Ontario Registered Pharmacy Technician (RphT) Practice Exam

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Which of the following pairs of medication could cause a major drug-drug interaction if taken together?

  1. Hydrocodone and Naproxen

  2. Warfarin and Aspirin

  3. Penicillin and Trimethoprim

  4. Glyburide and Metformin

The correct answer is: Warfarin and Aspirin

Warfarin and Aspirin could cause a major drug-drug interaction if taken together because both medications are blood thinners and can increase the risk of bleeding when combined. Hydrocodone and Naproxen may also interact, but it is typically a moderate interaction. Penicillin and Trimethoprim do not have a known interaction. Glyburide and Metformin are both used to treat diabetes and have a minimal potential for interaction. It is important to always consult a healthcare provider or pharmacist before taking new medications together to avoid potential interactions.

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